Ewelina Rojewska Selected Research

Minocycline (Cyclops)

1/2018	Pharmacological Inhibition of Indoleamine 2,3-Dioxygenase-2 and Kynurenine 3-Monooxygenase, Enzymes of the Kynurenine Pathway, Significantly Diminishes Neuropathic Pain in a Rat Model.
3/2016	Pharmacological kynurenine 3-monooxygenase enzyme inhibition significantly reduces neuropathic pain in a rat model.
1/2016	Direct and indirect pharmacological modulation of CCL2/CCR2 pathway results in attenuation of neuropathic pain - In vivo and in vitro evidence.
1/2016	Microglial Inhibition Influences XCL1/XCR1 Expression and Causes Analgesic Effects in a Mouse Model of Diabetic Neuropathy.
2/2015	The influence of microglia activation on the efficacy of amitriptyline, doxepin, milnacipran, venlafaxine and fluoxetine in a rat model of neuropathic pain.
12/2014	Involvement of pro- and antinociceptive factors in minocycline analgesia in rat neuropathic pain model.
11/2014	Minocycline prevents dynorphin-induced neurotoxicity during neuropathic pain in rats.
7/2014	Expression profiling of genes modulated by minocycline in a rat model of neuropathic pain.
1/2014	Delta-opioid receptor analgesia is independent of microglial activation in a rat model of neuropathic pain.
1/2014	Minocycline enhances the effectiveness of nociceptin/orphanin FQ during neuropathic pain.

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Ewelina Rojewska Research Topics

Disease

47	Neuralgia (Stump Neuralgia) 01/2022 - 11/2009
24	Pain (Aches) 01/2022 - 09/2013
11	Hypersensitivity (Allergy) 10/2021 - 01/2017
6	Diabetic Neuropathies (Diabetic Neuropathy) 01/2018 - 01/2013
6	Hyperalgesia 02/2016 - 01/2014
3	Chronic Pain 10/2021 - 01/2013
2	Chronic Disease (Chronic Diseases) 08/2020 - 01/2018
1	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2016
1	Respiratory Insufficiency (Respiratory Failure) 01/2016
1	Paralysis (Palsy) 11/2014

Drug/Important Bio-Agent (IBA)

22	Opioid Analgesics (Opioids)IBA 01/2022 - 01/2013
20	Morphine (MS Contin)FDA LinkGeneric 01/2022 - 09/2013
18	Analgesics (Analgesic Drugs)IBA 10/2021 - 01/2013
14	Minocycline (Cyclops)FDA LinkGeneric 01/2018 - 11/2009
13	LigandsIBA 08/2020 - 12/2013
9	Buprenorphine (Subutex)FDA LinkGeneric 01/2022 - 10/2015
7	ChemokinesIBA 07/2020 - 01/2015
5	CytokinesIBA 01/2021 - 11/2009
5	Neutralizing AntibodiesIBA 01/2019 - 01/2018
5	Messenger RNA (mRNA)IBA 01/2019 - 12/2013
5	Streptozocin (Streptozotocin)FDA Link 01/2018 - 01/2013
4	Proteins (Proteins, Gene)FDA Link 01/2019 - 12/2014
3	KynurenineIBA 10/2021 - 03/2016
3	Maraviroc FDA Link 07/2020 - 01/2016
3	incobotulinumtoxinA FDA Link 01/2018 - 11/2016
3	Type A Botulinum Toxins (Botox)FDA Link 01/2018 - 11/2016
3	InterleukinsIBA 01/2017 - 09/2013
3	Antidepressive Agents (Antidepressants)IBA 02/2015 - 01/2013
2	CC ChemokinesIBA 08/2020 - 11/2017
2	delta Opioid Receptors (delta Opioid Receptor)IBA 04/2020 - 01/2014
2	Dynorphins (Dynorphin)IBA 04/2020 - 11/2014
2	zaprinastIBA 02/2019 - 11/2018
2	preproenkephalinIBA 10/2018 - 11/2014
2	Opioid Receptors (Opioid Receptor)IBA 10/2018 - 01/2014
2	EnzymesIBA 01/2018 - 03/2016
2	Kynurenine 3-Monooxygenase (Kynurenine 3 Monooxygenase)IBA 01/2018 - 03/2016
2	Pharmaceutical PreparationsIBA 01/2016 - 01/2014
2	NociceptinIBA 01/2016 - 01/2014
2	Doxepin (Mareen)FDA LinkGeneric 02/2015 - 01/2013
2	Venlafaxine Hydrochloride (Effexor)FDA LinkGeneric 02/2015 - 01/2013
2	Milnacipran (Ixel)FDA Link 02/2015 - 01/2013
2	Amitriptyline (Elavil)FDA LinkGeneric 02/2015 - 01/2013
2	Fluoxetine (Prozac)FDA LinkGeneric 02/2015 - 01/2013
2	Pentoxifylline (Trental)FDA LinkGeneric 09/2013 - 11/2009
2	fluorocitrateIBA 09/2013 - 11/2009
2	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/2013 - 01/2013
1	Ketamine FDA LinkGeneric 01/2022
1	Oxycodone (Oxycontin)FDA LinkGeneric 01/2022
1	mirogabalinIBA 01/2022
1	CXC ChemokinesIBA 10/2021
1	Chemokine ReceptorsIBA 10/2021
1	CCR ReceptorsIBA 01/2021
1	HydrazinesIBA 01/2021
1	SB328437IBA 01/2021
1	Dipyrone (Metamizole)IBA 10/2020
1	Non-Narcotic Analgesics (Analgesics, Non Narcotic)IBA 10/2020
1	cenicrivirocIBA 07/2020
1	kappa Opioid Receptors (kappa Opioid Receptor)IBA 04/2020
1	Dopamine (Intropin)FDA LinkGeneric 04/2020
1	EnkephalinsIBA 04/2020
1	Kynurenic Acid (Kynurenate)IBA 02/2019
1	Chemotactic FactorsIBA 01/2019
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2019
1	LipopolysaccharidesIBA 12/2018
1	Phosphodiesterase InhibitorsIBA 11/2018
1	Cyclic GMPIBA 11/2018
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 11/2018
1	proenkephalinIBA 10/2018
1	Macrophage Inflammatory Proteins (Macrophage Inflammatory Protein 1)IBA 01/2018
1	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 01/2018
1	(+-)-dichlorobenzoylcyclopropane carboxylic acidIBA 01/2018
1	kynureninaseIBA 01/2018
1	AcidsIBA 01/2018
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2018
1	UCB 35625IBA 01/2018
1	Tryptophan Oxygenase (Tryptophan 2,3 Dioxygenase)IBA 01/2018
1	Blood Glucose (Blood Sugar)IBA 11/2017
1	Botulinum Toxins (Botulinum Toxin)IBA 11/2016
1	Interleukin-18 (Interleukin 18)IBA 03/2016
1	Carbon MonoxideIBA 02/2016
1	tricarbonyldichlororuthenium (II) dimerIBA 02/2016
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2016
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2016
1	Peptides (Polypeptides)IBA 01/2016
1	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 10/2015
1	2- (2- amino- 3- methoxyphenyl)- 4H- 1- benzopyran- 4- oneIBA 01/2015
1	parthenolideIBA 01/2015
1	Matrix Metalloproteinases (MMPs)IBA 11/2014
1	Interleukin-6 (Interleukin 6)IBA 11/2014
1	Neuroprotective AgentsIBA 11/2014
1	(trans)-Isomer 3,4- Dichloro- N- methyl- N- (2- (1- pyrrolidinyl)- cyclohexyl)- benzeneacetamideIBA 11/2014
1	U 0126 (UO 126)IBA 10/2014
1	Mitogen-Activated Protein KinasesIBA 10/2014

Therapy/Procedure

19	Analgesia 01/2022 - 09/2013
9	Therapeutics 01/2022 - 07/2014
5	Spinal Injections 08/2020 - 11/2017
3	Drug Therapy (Chemotherapy) 01/2022 - 07/2020
2	Intraperitoneal Injections 02/2015 - 11/2009
1	Ligation 11/2018
1	Injections 01/2016